how to lower muscle enzymes

The body builds up a store of glycogen from converted carbohydrates in muscle cells. High muscle enzyme levels are the result of damaged muscle tissue releasing enzymes into the blood or liver. Copyright © 2021 Leaf Group Ltd., all rights reserved. Your doctor may test your aldolase levels if you are experiencing weakness to determine whether the problem is in your muscles or your nerves, because muscle … 2018. Blood Tests to Diagnose Arthritis. Those giving rise to muscle pain are shown in Table 28.5.Myophosphorylase and phosphofructokinase deficiencies present with attacks of muscle stiffness, pain, and cramp which are brought on by moderate exercise and relieved by rest. Some medications may contribute to increased muscle enzymes 3. Liver cancer risk may be reduced by the consumption of citrus fruits. Other enzymes (LDH, aldolase, and transaminase) are normal in 11% to 68% of patients. A high muscle enzyme count is indicative of muscle damage. AST tends to rise with ALT if liver damage is present. In addition, selenium, zinc, and vitamins B, E and C are useful in fighting muscle inflammation that may lead to elevated muscle enzymes. If you have suffered from a serious physical trauma that causes muscle damage, it may require some healing time for enzyme levels to return to normal. Dr. Shavon Jackson-Michel is an expert in the field of health and wellness and has been writing for LIVESTRONG.COM since 2009. Prostaglandin E2 (PGE2), an eicosanoid that mediates inflammatory responses, also supports the function of muscle stem cells. etc. She is a university-level professor and a licensed naturopathic physician providing individualized consultations on natural and holistic approaches to chronic disease at her Bloomfield, NJ office. the same statin can be restarted at a lower dosage, or patients can try a different statin. 511 As a … The IQVIA Institute for Human Data Science. What Are the Causes of High Muscle Enzymes? Monitoring the levels of your AST, ALT, and CK throughout training can help you determine if your muscles are recovering as they should be. Exercise causes muscle pain too, so it is sometimes difficult to know if the pain comes from the statin or the exercise in someone who just started an exercise program. AST tends to rise with ALT if liver damage is present. Some prescription medications can also elevate muscle enzymes levels, although usually not dramatically. Happy to chat or do video chat with him so I can see what muscle problems he has. Certain muscle enzymes are specific to a part of the body and high levels of these could mean injury or defect that area. Whenever possible address and treat this condition and try to lower … Elevated muscle enzymes can be caused by conditions such as polymyositis, arthritis and muscular dystrophy. Elevated levels of bilirubin are considered to be a marker for lowered risk of cardiovascular disease. Trauma or injury. Try to increase resting periods in between workouts to decrease muscle enzyme levels immediately following a workout. The elevated liver enzymes … A high muscle enzyme count is indicative of muscle damage. They can also be high due to increased exercise. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, elevating liver enzymes on blood tests. Find ways to work oranges, grapefruits, lemons, and limes into your diet. Hospitalization is sometimes required to treat rhabdomyolysis. High muscle enzymes can also occur because of muscle-wasting disorders or because of damage to another organ that contains some of the same enzymes as your muscles, such as the liver. There are other potential causes of elevated muscle enzyme levels 3. Acta Neurol Scand. Your doctor may prescribe corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) to treat inflammation and other symptoms associated with high muscle enzyme levels. ; CPK-3 – which helps to handle bodily functions in the skeletal muscles. The liver uses thousands of enzymes to perform essential chemical processes as follows: What is muscular dystrophy? Rhabdomyolysis. Normally, there is very little creatine kinase found in the blood; elevated levels typically indicate muscle damage, recent … Other conditions that may be responsible for a high level of liver enzymes are celiac disease, herpes infection, Wilson’s disease, sepsis, and muscle inflammation. (You might see these enzymes also called metabolic enzymes or proteolytic enzymes.) Does he have muscular dystrophy? This enzyme has a number of functions in the body and is often found in the skeletal muscles and heart muscles. Check with your doctor to see if a medication might be causing high enzyme levels. Additional possible causes of elevated muscle enzyme levels include: * Recent generalized seizure, intramuscular injections or surgery * Multiple wasp or bee stings * Peripheral artery disease, especially affected the leg muscles * Malignant hyperthermia, which is a rare complication of general anesthesia * Gangrene * Certain inherited metabolic or enzymatic disorders. found that loss of PGE2 in aging mice contributes to loss of muscle and appears to be a consequence of increased activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme that degrades PGE2 (see the Perspective by Becker and Rudolph). These enzymes are not specific to the liver and are also found in muscle, heart, pancreas and brain. The body builds up a store of glycogen from converted carbohydrates in muscle cells. Medications can cause muscle injury and rhabdomyolysis. A study in Frontiers in Physiology illustrates this effect in women and girls. Creatine kinase is an important enzyme needed for energy production and muscle function. Does he have muscular dystrophy? Tutorial : Liver Enzymes Too High - ALT and AST. eHow wrote an article about how to lower them. Cook Your Own Low-Carb and Low-Fat Food Go Organic (Food and Products) The Best Foods for Lowering Liver Enzymes Drink Water, Limit Caffeine, and Cut Sugar Consume Healthy Proteins // Leaf Group Lifestyle. Robin McDaniel is a writer, educator and musician. They bind to molecules and alter them in specific ways. A male asked: my husband suffers from severe acute gout. Try to increase resting periods in between workouts to decrease muscle enzyme levels immediately following a workout. Another reason is that the injured area will have damaged muscles that could cause changes in enzyme levels. Your doctor will use several blood tests to help diagnose you with rheumatoid arthritis (RA) and other inflammatory conditions.. 370,510 Serum levels of all muscle enzymes usually decrease 3 to 4 weeks before improvement in muscle strength and rise 5 to 6 weeks before clinical relapse. Elevated ALT and LDH activities may also reflect liver disease associated with lipodystrophy and insulin resistance, although gamma glutamyl transferase is often helpful to discriminate these enzyme activities as muscle versus liver in origin. The level of the CK enzymes rises when you have damage to muscle cells in your body. These tests also can show how effective medication has been in reducing inflammation that causes muscle damage. Biga LM, Dawson S, Harwell A, et al. Vigorous or strenuous physical activity -- particularly if you're unaccustomed to it -- can transiently increase muscle enzyme levels. Rest in between workouts. When … If you are experiencing serious medical symptoms, seek emergency treatment immediately. Learn more about the powerful health benefits of systemic proteolytic enzymes. Thyroid, hormones and metabolic disorders may also contribute to muscular disorders. Let us explore all the causes of low liver enzymes and also their treatments. High enzyme levels may indicate muscular damage and may lead to muscle soreness. Determining the cause of elevated muscle enzymes usually involves additional blood tests. Sarcoplasmic membrane muscle enzymes are released when damage of the muscle cell occurs or its membrane becomes defective. Serum muscle enzymes such as creatine kinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alanine amino-transferase (ALT), and aldolase are often elevated in DM and PM. Creatine kinase (CK) is an enzyme found in your muscles. The level of the CK enzymes rises when you have damage to muscle cells in your body. Your friend is right that a muscle … By eating or drinking citrus fruits and its juices you can help your liver heal thus returning its enzyme level to the normal range. High Creatine Kinase Levels How Systemic Enzymes Improve Recovery. Several specific muscle enzyme deficiencies have been described since McArdle (1951) first drew attention to the disease that bears his name. can this cause high muscle enzyme … This can occur due to inflammation of the muscle caused by overexercise, muscular trauma or certain musculature conditions such as arthritis, muscular dystrophy and inflammatory muscle disease. Understanding neuromuscular disease Care. Therefore, elevated levels of so-called muscle enzymes might actually be due to a disease or disorder affecting another type of tissue or organ, such as the liver, brain or kidneys. Your Good Health: Muscle enzyme elevation can mean breakdown. Diet For Elevated Liver Enzymes. When muscle cells are damaged, these enzymes leak into the bloodstream and may causes elevated levels. Lipitor), rheumatologic disorders (eg. 0. For example, common muscle strains can cause your creatine phosphokinase levels to elevate. What is cardiomyopathy in adults? Clini- cally important drugs that interact with statins and increase the risk of adverse effects include Get tested for muscular disorders. Eating more plant-based foods, like fruits and veggies, as well as whole grains and healthy fats may reduce your risk of heart disease. ; CPK-2 – which helps to handle bodily functions in the heart. A variety of diseases and conditions can cause high muscle enzyme levels. Add anti-inflammatory foods into your diet. An example of particular concern is a heart attack, in which a sudden blockage in blood supply to the heart leads to death of heart muscle cells in the affected area. ANSWER. Your doctor may prescribe corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) to treat inflammation and other symptoms associated with high muscle enzyme levels. Examples include cholesterol-lowering statin medications, and certain medicines for heart disorders, Parkinson disease and HIV, among others. ... so those who stay active might not have lower values. Enzymes are protein-based compounds that facilitate specific chemical reactions in living organisms. Systemic Proteolytic Enzymes dissolves excess fibrin that forms scar tissue, adhesion's, and growths that create inflammation and slow down the circulatory system.. Around age 27 these enzymes start depleting drastically. Proteolytic enzymes have powerful anti-inflammatory properties, but they do so much more than relieve pain and inflammation. Getting fit offers you the best way to lower your creatine kinase response to exercise. In most cases, transient muscle enzyme level increases related to overexertion or mild muscle injuries pose no long-term health risk. Low liver enzymes can be caused by many sorts of diseases. Creatine kinase (CK) is an enzyme found in your muscles. Normally, there is very little creatine kinase found in the blood; elevated levels typically indicate muscle damage, recent … Often, organs and muscles must have been damaged so that the levels of CK enzyme spike up. Certain muscle diseases are associated with elevated muscle enzyme levels, reflecting underlying muscle damage. Enzymes are proteins that help your body's cells do their jobs. 1,3,5,10,48,329 Some patients have a persistent elevation of serum muscle enzyme levels late in the course, either associated with ongoing muscle inflammation or in some cases without any other clinical indication of muscle inflammation. Lower levels of plasma CK in older female subjects have been attributed to a decline in circulating neutrophils with age which may, in part, be due to reduced oestradiol levels and endogenous antioxidant status . McDaniel enjoys writing, blogging, web design, singing and playing bass guitar. Elevated lactate dehydrogenase levels may indicate cell damage of any kind. Reduce or avoid sugar, salt, and fats. Eating citrus fruits or drinking their juices will help the liver heal, bringing enzyme levels back to healthy levels. Elevated liver enzymes are a symptom of overuse, but simple diet changes can lower enzyme levels back to a healthy balance. The liver is one of the most important organs in the human body. Enzyme Abnormalities and Muscle Toxicity R. CLARK GILLETT, JR., MD, and ANGELICA NORRELL, ... thy from low to moderate dosages (40 mg per day or less) is similar to that with placebo chest compressions after cardiac arrest. Updated July 16, 2019, American Heart Association. According to pubmedcentral.nih.gov, when muscles contract with a high degree of tension, it may lead to muscle fiber damage. This group of enzymes helps reduce inflammation and supports immune function, helping to combat muscle-wasting conditions. Diet for patients with elevated liver enzymes include; Drink a lot of water; Do not eat fry and spicy food. When this occurs, the body will produce certain enzymes quicker and in large quantities. Try the Mediterranean diet. Low muscle enzymes: May mean he is weak. Creatinine is a blood chemical waste product made when you use muscles. Talk to your doctor about alternative medications if your medication is contributing to high muscle enzyme levels 3. 0 0 1 Exercise can significantly affect your blood test results, especially when it comes to liver enzymes. How to Lower High Muscle Enzyme Levels . Where there are elevated levels of CK enzyme in the blood, it could be due to a number of reasons. Glycogen, a fuel used by muscles for energy, is depleted during work and restocked when a horse rests. What Does a High SGOT in a Liver Function Test Mean? 0 thank. // Leaf Group Lifestyle, Causes of Muscle Pain in the Hands and Feet. Send thanks to the doctor. Papain: This enzyme from tropical fruits such as papaya helps break down large protein molecules into smaller units for easier digestion. Low muscle enzymes: May mean he is weak. Potential liver and muscle damage may be assessed by examining the enzymes in the blood. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Your Good Health: Muscle enzyme elevation can mean breakdown. Understanding the function of the liver, its role in recovering and responding to exercise, and how this affects critical biomarkers in a blood test will help you better interpret your results and draw an accurate conclusion. Muscle enzyme tests (CPK, aldolase) These tests measure the amount of muscle damage (in some rheumatic diseases, damaged muscles release certain enzymes into the blood). Your SGOT levels may also elevate because of any type of muscle damage. Steps. While most heart attacks cause chest pain or discomfort, some do not. The cell membranes may then be damaged if the horse is forced to continue work, which allows muscle enzymes and myoglobin to leak into the bloodstream. Citrus fruits are also known to reduce the risk of liver cancer. Protease enzymes are particularly important for those who have trouble absorbing protein. Begin working on including oranges, lemons, grapefruits, limes, and lemons as part of your diet. 0 comment. The high enzymes aren't the issue, the muscle damage is. Your friend is right that a muscle … Secondary myopathy due to systemic diseases. Trainers refer to this phenomenon as the repeated bout effect. Low levels are likely caused by severe liver damage and high levels are typically due to dehydration or excessively high protein intake. They are: CK-MM, found in your skeletal muscle … The high enzymes aren't the issue, the muscle damage is. CPK-1 – which helps to handle bodily functions in the brain and lungs. Muscle enzyme levels may rise for a variety of reasons, including autoimmune disorders and infections. Recent generalized seizure, intramuscular injections or surgery, Peripheral artery disease, especially affected the leg muscles, Malignant hyperthermia, which is a rare complication of general anesthesia, Certain inherited metabolic or enzymatic disorders. Palla et al. Preparing your body for an upcoming workout will decrease your enzyme response. To support normal liver enzyme levels, incorporate macronutrients like high-quality protein, healthy fats, complex carbohydrates and micronutrients like vitamins and minerals into your diet. Some are temporary and pose no long-term health risk but others are potentially life threatening. Blood levels of muscle enzymes, including CPK, SGOT, SGPT, and LDH, as well as blood and urine myoglobin are used to diagnose and monitor rhabdomyolysis. Sarcoplasmic membrane muscle enzymes are released when damage of the muscle cell occurs or its membrane becomes defective. Muscle enzyme levels may rise for a variety of reasons, including autoimmune disorders and infections. Muscle trauma due to participation in contact sports or an accident also commonly causes a temporary elevation in muscle enzyme levels. Copyright © 2021 Leaf Group Ltd., all rights reserved. Systemic enzymes play a vital role in your metabolism, including muscle and tissue recovery. Anti-inflammatory over-the-counter medications might be useful for pain management 3. Reviewed and revised by: Tina M. St. John, M.D. Clinical definition of sarcopenia. If you have suffered from a serious physical trauma that causes muscle damage, it may require some healing time for enzyme levels to return to normal. Brigham and Women’s Hospital. Examples include: Many systemic diseases -- those that have widespread effects in the body -- lead to deleterious effects on the muscles that can provoke muscle enzyme elevations. Athletes have more of this enzyme in their blood, but so do obese and overweight people. Elevated muscle enzymes can be caused by conditions such as polymyositis, arthritis and muscular dystrophy. So for example if you get elevated muscle enzymes because of Lipitor, then if you stop Lipitor the … ... so those who stay active might not have lower values. Vigorous or strenuous physical activity -- particularly if you're unaccustomed to it -- can transiently increase muscle enzyme levels. Electromyography. Enzyme markers are blood tests that analyze specific enzyme activity in the body. When you have high muscle enzyme levels -- including creatine phosphokinase (CPK) and aldolase -- it indicates you may have a possible inflammatory muscle disease. In addition to direct liver injury, interactions between conventional medicines and herbal products have been described, so the doctor should inquire about the use of herbal products and prevent concomitant use with conventional medicines in which such interactions have been described. Additional possible causes of elevated muscle enzyme levels include: The term muscle enzymes is somewhat misleading as the enzymes that occur in muscles also occur in other body tissues. Muscle trauma due to participation in contact sports or an accident also commonly causes a temporary elevation in muscle enzyme levels. ENZYME EDUCATION | Enzymes are proteins that act as catalysts in the body, enabling metabolic processes to occur at lightning speed. Current Opinion in Pharmacology: Drug Induced Rhabdomyolysis, Skeletal Muscle: Idiopathic Inflammatory Myopathies -- Pathogenic Mechanisms of Muscle Weakness, Deutsches Ärzteblatt International: Creatine Kinase Levels After Exercise, Frontiers in Neurology: Stepwise Approach to Myopathy in Systemic Disease, Deutsches Ärzteblatt International: Treatment Options for Statin-Associated Muscle Symptoms, BMJ: Investigating Mildly Abnormal Serum Aminotransferase Values, Mayo Medical Laboratories: Creatine Kinase (CK), Serum, Mayo Medical Laboratories: Aldolase, Serum, Cleveland Clinic Journal of Medicine: Approach to Asymptomatic Creatine Kinase Elevation, Finsterer J, Löscher WN, Wanschitz J2, et al. ; Aspartate Transaminase (or AST for short): AST is not quite as specific as ALT for liver damage as it is also found in skeletal muscle, heart muscle, and kidney tissue. Certain muscle diseases are associated with elevated muscle enzyme levels, reflecting underlying muscle damage. This enzyme has a number of functions in the body and is often found in the skeletal muscles and heart muscles. Updated March 31, 2016, Santilli V, Bernetti A, Mangone M, et al. Now, when you view your liver group, your paragraph will inform you whether or not muscle damage may be skewing the results of your liver enzymes based on your CK. According to springerlink.com, muscle membranes release enzymes when they become defective or damaged. 2016;134(6):388-402. doi:10.1111/ane.12576. The liver is a crucial part of the body without it your body cannot remain healthy and strong for a long time. In most cases, transient muscle enzyme level increases related to overexertion or mild muscle injuries pose no long-term health risk. High levels can tell us if there is muscle, heart, or brain damage. Enzymes can also be used in medical and industrial contexts. See your doctor without delay if you experience muscle-related signs and symptoms, such as weakness, pain, soreness or muscle wasting. 0 0 1 This list goes on for awhile. If you are experiencing serious medical symptoms, seek emergency treatment immediately. The 3 types of CK are called isoenzymes. Method 1 of 3: Recognizing Liver Disease Dr. Jackson-Michel is a doctoral graduate of the University of Bridgeport College of Naturopathic Medicine. A variety of muscle diseases and conditions can elevate muscle enzyme levels. Tutorial : Liver Enzymes Too High - ALT and AST. Serum muscle enzymes such as creatine kinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alanine amino-transferase (ALT), and aldolase are often elevated in DM and PM. Learn about home remedies to naturally lower your creatinine levels. Learn about different types, such as the CPK isoenzymes test. These so-called silent heart attacks are sometimes detected due to elevated muscle enzyme levels. Updated July 2019. XanEdu Publishing Inc; 1st edition; 2013:976-984, Centers for Disease Control and Prevention. There might be an imbalance in the enzymes so that other enzymes may have to be synthesized to compensate. Recovery Times for Serratus Anterior Rowing Injuries. Try to avoid processed and packaged foods, and instead choose whole grains, fruits, vegetables, legumes, low-fat dairy, and lean meats and fish. If you have high muscle enzyme levels in your blood, your doctor will evaluate any symptoms you have and perform other necessary tests to find out the cause. A variety of muscle diseases and conditions can elevate muscle enzyme levels. According to sportsinjurybulletin.com, foods that contain omega-3 and omega-6 fatty acids such as fish, nuts, olive oil and sunflower oil can help decrease inflammation. Rhabdomyolysis can cause muscle pain and weakness. Muscle tissue, In: Anatomy & Physiology. High Creatine Kinase Levels The muscle enzymes should correct once you correct the cause. eHow wrote an article about how to lower them. Creatine kinase (CK) levels drop naturally as time passes; no supplements can be taken to lower levels of the enzyme, explains HealthTap contributor Dr. Alvin Lin. Although statins are the most effective oral medications for lowering your cholesterol, other types of drugs also are available. They can also be high due to increased exercise. Monitoring your levels for overtraining. High CPK-3 levels can be a sign of muscle stress, a crush injury, or injury due to: muscle damage, dystrophy, or inflammation. Consider other cholesterol-lowering medications. Alanine Transaminase (or ALT for short): ALT is produced in the liver cells known as hepatocytes and is a very specific marker of liver cell damage. 2014;11(3): 177–180. She holds a master's degree in higher educational leadership from Florida Atlantic University in Boca Raton as well as a bachelor's degree in elementary education. The Mediterranean diet is a heart-healthy meal plan that limits the intake of salt, bad fats, and red meat. Muscle enzymes become elevated because of damage to muscle which results in the release of these enzymes into the blood stream. How to Lower High Muscle Enzyme Levels . The GOT is constituted by two isoenzymes, one cytoplasmic and other mitochondrial, while GPT is exclusively cytoplasmic. Clin Cases Miner Bone Metab. Enzymes are proteins that help your body's cells do their jobs. Muscle mass and function gradually decline with age, and cell apoptosis may have a role in age-related sarcopenia . I started using enzymes in earnest a few years ago, basically testing them out to see if they would make a difference in nutrient absorption and digestion (which is critical both in fat-loss and in muscle-building and a host of other bodily processes). Enzymes help speed up chemical reactions in the human body. Exercise can significantly affect your blood test results, especially when it comes to liver enzymes. ; Why would we want to see this enzyme activity? Healthy elevations in bilirubin have also been known to be caused by increased … Basic facts about muscles. She is pursuing a Ph.D. in adult in community education. doi:10.11138/ccmbm/2014.11.3.177. Dermatomyositis), genetic disorders (Duchenne muscular dystrophy), etc. Elevated liver enzymes often indicate inflammation or damage to cells in the liver. Often, organs and muscles must have been damaged so that the levels of CK enzyme spike up. Breadmaking, cheesemaking and beer brewing all depend on the activity on enzymes -- and enzymes can be … They are: CK-MM, found in your skeletal muscle … According to medicinenet.com, statin drugs may increase the risk of muscle inflammation, which can lead to elevated muscle enzyme levels. Muscle cells contain a variety of enzymes with particularly high concentrations of those involved in generating energy to power the muscles. Elevated muscle enzyme is caused by trauma, injury, certain medications and a number of ailments. These tests also can show how effective medication has been in reducing inflammation that causes muscle damage. ... Creatine Kinase, an enzyme found in our muscles, is another marker of muscle damage that follows the same pattern as AST and ALT after strenuous exercise. The 3 types of CK are called isoenzymes. Muscle damage can be caused by neuromuscular disorders such as muscular dystrophy. Glycogen, a fuel used by muscles for energy, is depleted during work and restocked when a horse rests. Your doctor might also order other diagnostic tests. It is also the largest gland in the body, situated below the right rib cage just above the abdomen. ... heart muscle, and kidney tissue. Examples include: There are other potential causes of elevated muscle enzyme levels 3. Elevated liver enzymes indicate damage to the liver cells and should never be ignored. Chapter 10. According to medicinenet.com, statin drugs may increase the risk of muscle inflammation, which can lead to elevated muscle enzyme levels. Updated December 2, 2019, Myasthenia Gravis Foundation of America, Inc. MG facts, Medline Plus. Understanding the function of the liver, its role in recovering and responding to exercise, and how this affects critical biomarkers in a blood test will help you better … Where there are elevated levels of CK enzyme in the blood, it could be due to a number of reasons. Muscle enzyme tests (CPK, aldolase) These tests measure the amount of muscle damage (in some rheumatic diseases, damaged muscles release certain enzymes into the blood). The cell membranes may then be damaged if the horse is forced to continue work, which allows muscle enzymes and myoglobin to leak into the bloodstream. See your doctor without delay if you experience muscle-related signs and symptoms, such as weakness, pain, soreness or muscle wasting. Enzymes are proteins produced within cells that enable them to carry out their metabolic and biological functions. Seek emergency medical care if you experience difficulty breathing or muscle weakness that develops rapidly. Muscles that are overstressed due to overexertion may release higher levels of enzymes. 0. Before the protein and carbohydrates we eat can be used for muscle growth, stored enzymes must be released from the digestive system. Rest in between workouts. There are many causes of elevated muscle enzymes from medications (eg. What Foods Help Lower Elevated Liver Enzymes? Happy to chat or do video chat with him so I can see what muscle problems he has. Creatine kinase (CK) levels drop naturally as time passes; no supplements can be taken to lower levels of the enzyme, explains HealthTap contributor Dr. Alvin Lin. Thyroid, hormones and metabolic disorders may also contribute to muscular disorders.

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