collagen and breast

[11] Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance – https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1030-y#:~:text=Increased%20collagen%20expression%20and%20deposition,protein%20within%20the%20collagen%20superfamily. Collagen is the most common protein in the human body, and it has a very important role. Although known for its use in creams or beauty treatments, collagen is the most abundant protein in our bodies and an essential component of bones, ligaments, tendons, cartilage and skin. Collagen is also the major component of something called the extracellular matrix, or ECM. So far so good. A family member bothered severely the last nine months and not able to get under control,even with steroids. Human bodies create collagen naturally. by Marnie | Sep 28, 2020 | Breast Cancer and Nutrition, Collagen | 6 comments. Re the ulcerative colitis, I’m afraid that’s not within my area of knowledge, so I wouldn’t care to comment. Collagen is a fibrous protein that forms a connective tissue that gives skin support. Collagen is a long chain of proteins and sugars (known as a glycoprotein), and is the most abundant protein within our bodies. Collagen is a base of healthy hairs, skin and nails. We also discuss the role of a collagen-dependent protease, pappalysin-1, in postpartum breast cancer and its role in activating both insulin-like growth factor signaling and discoidin domain collagen receptor 2, DDR2. Often enough it is the case that when the body produces a substance, it might be good for the body but when used as a supplement it can be detrimental. Collagen injections for breast augmentation There’s not enough long-term evidence to support the use of collagen injections for breast augmentation. Our bodies produce less collagen as we age, which is why there is a huge market for collagen supplements (which are made from animal bones, skin, or cartilage). Because it has been observed that breast cancer patients with high levels of collagen in their tumors often have less than optimal outcomes, it is advisable to steer clear of collagen supplementation if you have active cancer tumors in your body. But this interaction between the ECM and cells can also play an important role in the growth of a tumor and its ability to grow and spread. Your emails and posts not only gave me information but lots of courage.” Susan Z, Canada. If any filler is recommended to enhance the breast, I would recommend another opinion. Hi, I've had Dermapen treatments that have helped to blend in unsightly whitish stretch marks, and would like to continue to do so. It is found throughout our bones, teeth, muscles, tendons, and skin. 8 Ways To Build A Super Strong Immune System, Marnie’s Must-Have Supplements for Breast Health, Essential Oils for Overall Health and Specific Health Problems, Marnie’s 50 Favorite Cancer Healing Recipes Cookbook, epigenetic factors to reduce breast cancer. I also wanted to thank you for being with me during my treatments. I agree with you Marnie. The tetraspanin TM4SF1 was previously identified as a molecule that promotes metastatic outgrowth in mice injected with dormant cancer cells. GET MY BEST TIPS on healthy ways to beat breast cancer and prevent recurrences by signing up for my free e-newsletters and eBooks. Thank you for the article. Breast cancer cells were cultured on 8 µm pore Boyden chambers for 24 h to monitor changes in rates of migration induced by the substrates (n = 3). However, function and regulation of membrane-associated collagen in breast cancer have not been determined. They are promoting it hard – like a new wonder drug – for better skin and nails, better hair (which I suspect is the reason people are asking me about collagen, to help them with hair loss due to breast cancer treatments), better gut health, for weight loss, and for its so-called anti-aging benefits. Fig. PLease keep us informed if you have any more information on this matter. Because we do not have a definitive answer on whether collagen supplementation is safe for those whose tumors are gone, here’s what I would recommend. Hi Debbie, (If you read about Chiyomilk’s program the lady who grew from Cup B to Cup E naturally, she includes collagen in her program as well! Collagen is a protein found in our bodies that helps to bind cells and tissues together. Collagen injections are an attractive option for many patients, due to the cost effectiveness and because unlike traditional augmentations, they do not require major surgery. Your email address will not be published. According to Sara Musetti, scientist and co-founder of OncoBites, a cancer research outreach blog, cancer takes all the good things about collagen and turns them into a nightmare. Online ahead of print. "Collagen is the most abundant protein in the body," says Eliceiri. Collagen is the most abundant protein in our bodies, especially type 1 collagen. Collagen is important to bounce back to days where you was before. Welcome to the Marnie Clark Breast Care Community. The structure of collagen fibers may play a key role in the spread of breast cancer, with implications for clinical prognosis and treatment. If you’ve noticed, there are a number of companies promoting collagen supplements at the moment. In … What Does Collagen Have to Do with Natural Breast Enhancement? A 2019 review of medical studies on collagen [12] called collagen a “double-edged sword” with regard to cancer. Glycine is the amino acid of greatest abundance in collagen. A 2013 study [3] found that DDR2, a protein that sits on the surface of tumor cells and binds to collagen, activates a pathway that encourages the spread and invasiveness of tumor cells. The ECM is a network of molecules such as collagen, enzymes, fibers, proteins and glycoproteins that exist outside of our cells – sort of like a scaffold, in order to support the cells with which they are associated. Collagen has many important functions, including providing your skin with structure and strengthening your joints and bones. 1: Hydroxylysine collagen crosslink abundance correlates with human breast cancer aggression. The theory for collagen suppleme… I’d have your family member speak with a naturopath well versed in that disorder. A protein substance that is like a glue and unifies skin tissues and helps maintain its structure and thus give a youthful look. What about collagen supplements for sagging breasts? Collagen is a fibrous protein that forms a connective tissue that gives skin support. In collagen, these strings are wound and linked causing thick strands called fibers that provide strength and flexibility to our tissues. A similar rearrangement of collagen has also been found in breast cancer, head, neck, esophageal and colorectal cancers. A 2018 study [9] found that type 1 collagen promoted breast cancer cell growth and the ability to migrate to distant parts of the body. Collagen is probably not the filler of choice as it is quickly dissolved and doesn't appear to give the longer-lasting collagen stimulatory effect of other products like hyaluronic acid. I threw out my collagen because I had the same worry as you. The ECM provides structural and biochemical support to the cells surrounding the ECM and there is an interaction between cells and the ECM – it helps to inform cells about growth and many other functions. Improved blood flow in breast tissue isn’t going to dramatically increase your breast size but it may help prevent breast sagging. Also, would collagen play any kind of role in ulcerative colitis???? Clinical studies have proven that also helps to reduce the joint pain caused by wear, loss of bone density and skin wrinkling (see “Scientific studies”). Yes, this information on collagen was surprising to me as well. A protein substance that is like a glue and unifies skin tissues and helps maintain its structure and thus give a youthful look. [1]. The word collagen comes from the Greek word meaning glue. The interaction between cells and the ECM provides for things like regulation of gene expression, cell differentiation and growth. Recommended Natural Breast Enhancement Products. * Today, you can find the word ‘collagen’ on labels of various cosmetic products – pills, creams, powders etc. Marnie….WOW!and that’s what my health professional contacts that helped me make my decisions regarding DCIS treatment had to say when they read this. Thanks for helping. Collagen has been shown to help reduce joint pain in non-pregnant individuals leading to the hypothesis that it could do the same during pregnancy and the early days of postpartum. Collagen supplements have become very popular in recent years; and for good reasons, because Collagen is the major component of connective tissues that make up several body parts, including tendons, ligaments, skin and muscles. Collagen is a protein — the most plentiful protein in your body, according to the Cleveland Clinic, although production decreases as you age.It's in your muscles, bones, tendons, ligaments, organs, blood vessels, skin, intestinal lining and other connective tissues. Collagen is the most common protein found in your body. I promise to do my utmost to keep you informed and empowered on your healing journey… and beyond. Researchers stated that DDR2 might very well be a good therapeutic target for treating metastasized breast cancer. Cancer cells use and reshape collagen, utilizing it to improve invasiveness, increase the ability of cancer cells to resist dying off, for building new blood vessels (angiogenesis), and many other functions, which gradually promotes cancer progression. Native collagen type II is a protein that is part of cartilage, bone, and other tissues in animals and humans.Most collagen type II in supplements comes from chicken. It is clear that researchers believe that many types of collagen promote tumor growth. I’ve been healthy and recurrence-free since 2004 and in 2012 I became a Breast Cancer Coach because I became aware of the fact that whilst there is now a wealth of information on the Internet, much of it is confusing, conflicting, and sometimes just wrong! When you join my virtual family you will receive my informative newsletter PLUS my gift to you, these 2 eBooks valued at $47 to empower and support you on your breast cancer journey. This is believed to give more firmness, perkiness, and elasticity to your breasts. That was the only study I found that showed a particular type of collagen suppressed tumor growth. Well stated, Gabriele! To investigate whether collagen prolyl hydroxylase expression has clinical significance for breast cancer prognosis, we analyzed P4HA1 and P4HA2 gene expression in human breast cancer using the Oncomine database , which revealed that P4HA levels were significantly greater in breast cancer tissue than in normal breast tissue . He said that after digestion, collagen disintegrates into amino acids, which are also found in the proteins of commonly-consumed foods like eggs, meat and beans. This is the start of the aging and loss of flexibility of the tissues. Collagen XIII is a type II transmembrane protein within the collagen superfamily. “It would be more dangerous if you found the collagen effective, because then estrogen must have been added to the product.”. Marnie. Warmest regards, Fibronectin and collagen-I significantly increase the rate of breast cancer cell migration. Hi Barney, Marnie. You can see more about my journey on my page Breast Cancer Diary. Indeed, Matsundo and Toledo characterize injected fat grafting as an approach that involves "major advantage… However, collagen is the major component of the tumor microenvironment and has been shown to participate in cancer development. Gao et al . Thus, collagen enhancement presents a relatively low-risk, quick and effective option for those seeking to enlarge the breasts and/or buttocks. It’s found in muscles, bones, skin, blood vessels, digestive system and tendons. Learn how your comment data is processed. Needless to say, I have stopped taking the collagen. Another 2018 study [10] also showed that collagen type 1A1 promoted breast cancer metastasis. Fig. Some of the herbal formulas may also help regenerate your collagen which is the protein in your bodily tissues that provides structure. “Thank you for the email and the meaningful words. Increased collagen expression and deposition are associated with cancer progression and poor prognosis in breast cancer patients. So it is my duty to help you unconfuse and untangle all that information, and find what works for YOU. Collagen is a large molecule and complex and therefore can be poorly absorbed by the digestive system. Also, collagen-rich environments lack oxygen (known as hypoxia), which intensifies cancer progression.Â, One Chinese doctor at a burns unit in a Beijing Hospital (who did not wish to be named) clearly held a dim view of collagen supplementation, calling them absolutely useless. Another 2014 paper [5] stated that both hyaluronan (another glycoprotein found in the ECM) and collagen VI are upregulated (promoted) in breast cancer, generating a microenvironment that promotes the progression of a tumor and also metastasis.Â, In her 2015 YouTube video “Understanding the Role of Collagen in Breast Cancer” [6], Dr Patricia Kelly explains that breast cancer cells use the collagen network in order to travel to other parts of the body.Â. Quite often eating foods that are high in protein in large proportions may even cause difficulties in digestions, causing bloating and discomfort. It is also part of the wall of blood vessels, eye cornea, dentin, and scalp gums and connective tissue that surrounds and protects our muscles and vital organs. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins, discoidin domain receptors, tyrosine kinase receptors, and some signaling pathways. The review reiterated the fact that our bodies have lots of collagen and require it for proper functioning. ), Numerous scientific studies, carried out by research teams in different countries, have shown that taking daily 10 grams of highly digestible collagen (pre-digested or hydrolyzed  helps nourish and regenerate the tissues of our body whose structure consists of collagen, especially the joints, bones, and skin.). Collagen is the protein responsible for skin elasticity. And with everyones genes being so individual it is hard to decide what the right choice might be. Collagen Side Effects Can be Intense — So Why Do People Take It? Unlikely: The late studies relating dense breasts, with dense collagen, to increased risk of breast disease may point towards an association, but nothing is proven so far. Required fields are marked *. Before we get into that perhaps we should first have a look at what collagen supplements are and why you would want to take them and then we can look at the safety aspect for pregnant and breastfeeding women. Collagen is found in skin, hair, cartilage, and many other tissues, and it is absolutely vital. Musetti tells us “. It's in your skin but also in tendons, cartilage, bones, blood vessels, teeth and many other body parts. Marnie, Your email address will not be published. These end point assays were analysed through the dissolution of CV and measuring the absorbance at 595 nm. This aging can be slowed down by consumption of food that is high in protein and collagen. Micro needling / collagen induction therapy for stretch marks post breast augmentation? Now that we know fenugreek’s primary benefit in breast enlargement is increasing the production of estrogen, a few biological notes are helpful to understand how it works. Benefit #5: Strength your joints Collagen provide essential protein that have massive impact on health of skin, hairs and nails. Collagen helps shape tissue and keep it strong and firm. A very common question asked by pregnant and breastfeeding mothers is whether it is safe to take collagen while pregnant and breastfeeding. A 2015 animal study [8] found that type III collagen (col3) suppressed the carcinogenic microenvironment of a developing tumor. Disseminated breast cancer cells often enter a state of dormancy in metastatic niches, and their reactivation causes the emergence of metastatic disease even many years later. Sleep. It is being noticed that after pregnancy hair became radiant, nails get brittle. Well even though your skin can still absorb some of it, it would most likely be in such a tiny amount, I really don’t think this would be a problem. In this study, the impact of a type I collagen matrix orientation and fibrous architecture on cell proliferation and response to estrogen receptor (ER) therapy were examined using estrogen-dependent breast tumor cells (MCF-7 and T-47D) cultured in a hormone-restricted environment. Furthermore, not all the collagen we eat is used by the body as effectively and quickly. Not just during pregnancy, but even during breastfeeding and postpartum, the intake of collagen greatly helps to reduce hair loss and degradation. ... Collagen is sold in powdered form, and also used in expensive protein bars, beauty gummies, and drinks. I have 20 years of experience in natural medicine. But is it safe for breast cancer survivors? As the most abundant protein in the body, collagen is the intracellular “glue” that holds us together, all the way from our cells to our organs and even out to our skin. To address that, collagen is … Lovely to hear from you, it’s been awhile! You can probably find a good one online, but let me know if you need help (I’d need their location). 2020 Nov 30. doi: 10.1038/s41563-020-00849-5. From pre-menopausal women, athletes, seniors or with diets low in animal protein, overweight, sedentary habits or conduct work load weights are risk groups should supplement their diet with highly digestible collagen. I don't know how similar collagen is to hyaluronic acid, but I did read an article that stated hyaluronic acid did promote metastasis significantly by aiding in the cancer's transport. If you’ve noticed, there are a number of companies promoting collagen supplements at the moment. Here's why a stage 4 breast cancer diagnosis can be so frightening. For those who want to enhance the breast area or buttocks, there are many options. [12] The role of collagen in cancer: from bench to bedside – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744664/, [13] Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells – https://www.sciencedirect.com/science/article/pii/S2352396416304674. My subscribers also get a treasure trove of info on nutrition, supplements and lifestyle tips on surviving breast cancer. Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. 2: LOX and PLOD2 are enriched in triple negative breast cancer and … Foods that are high in collagen are meat broths and fish, and jellies, as well as some traditional dishes such as tripe or trotters. Like all proteins, collagen is composed of long chains of amino acids. What about using shampoos with collagen in them? You are quite welcome, hope it helped you in some small way. Interestingly, it appears that different types of collagen can also suppress tumor growth. GetCurvyNow's New and Improved Get Hourglass Body Formula, Click here to buy Dr. Axe’s Collagen Product on Amazon, CLICK here to Check out the Collagen Product We Recommend, Garcinia Cambogia – The 'Holy Grail' of Weight Loss Supplement, Phen375 : The Non-Prescription Appetite Suppressant and Fat Burner, GetCurvyNow's Complete Guide to Hourglass Body, GetCurvyNow's Powerful Guide to Naturally Bigger Breasts. I found that fascinating – this ability of collagen to hide tumor cells in protective pockets so that immune cells and chemo drugs can’t get to them. By the time we hit 40 years old, the production of collagen is lowered by half when compared to how much collagen production there was during our adolescence. This fibrous protein is everywhere: in tendons, muscles, bone, cartilage and skin. Collagen is more than just another pretty face.  In 2004/05 I battled breast cancer myself. Over time, the amount of collagen in the body decreases, leading to sagging skin and deteriorating bones. Answer: These are excellent questions if you are considering taking any type of dietary supplement. It also plays a role in joint and bone health. Collagen … Non-tumorigenic breast cell line MCF10A showed slight changes in NADH free:bound ratio only on the low-density collagen surface, indicating that this … You can also “like” me on Facebook (Marnie Clark, Breast Health Coach) to get my inspirational snippets, news and updates. In this review, we summarize the current understanding of the role of involution and describe the role of collagen in this setting. "We have shown how increased collagen in the breasts could increase the chances of breast tumors spreading and becoming more invasive," says Gregory D. Longmore, MD, professor of medicine. I am assuming this is taking collagen in pill form. Why is Collagen Important in Natural Breast Enhancement? Collagen benefits are so striking because this protein is what helps give our skin strength and elasticity, along with replacing dead skin cells. The US National Cancer Institute estimates that 12.9 percent of women will be diagnosed with breast cancer in their lifetime, making it a serious health issue for women across the globe. I’ve been getting an increasing amount of questions about whether collagen supplements are safe for breast cancer survivors, and indeed, I’ve run across a few articles lately warning us about collagen supplementation. Warmest regards, As we get older, the production of this protein generated by cells is reduced. However, in reality, we fail to eat as healthy in order to receive enough nutrients and the required amino acids. Estrogen is the hormone that stimulates breast growth, which is physically obvious during puberty and during pregnancy. If you are considered to be cancer free and you believe collagen will be of benefit to you, [1] Video: Extracellular Matrix: https://www.khanacademy.org/science/biology/structure-of-a-cell/cytoskeleton-junctions-and-extracellular-structures/v/extracellular-matrix, [2] Article: The Double-Edged Sword of Collagen — https://oncobites.blog/2019/12/06/the-double-edged-sword-of-collagen/, [3] The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis — https://www.nature.com/articles/ncb2743, [4] Collagen as a double-edged sword in tumor progression – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980040/, [5] Collagen VI and Hyaluronan: The Common Role in Breast Cancer – https://www.hindawi.com/journals/bmri/2014/606458/, [6] Video: Understanding the Role of Collagen in Breast Cancer – https://youtu.be/uAHpvwv9iqg, [7] Cancer reactivated by collagen – https://stke.sciencemag.org/content/9/437/ec165, [8] Type III Collagen Directs Stromal Organization and Limits Metastasis in a Murine Model of Breast Cancer — https://www.sciencedirect.com/science/article/pii/S0002944015001285, [9] Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973854/, [10] Collagen – col1A1 – Promotes Metastasis of Breast Cancer and is a Potential Therapeutic Target —, https://www.discoverymedicine.com/Jing-Liu/2018/05/collagen-col1a1-promotes-metastasis-of-breast-cancer-potential-therapeutic-target/.

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